Welcome to the Peyrégne Lab!

Institut Jacques Monod, 15 Rue Hélène Brion, 75013 Paris, France.

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CONTACT US:

stephanepeyregne (at) gmail.com

Understanding human biology and health has advanced rapidly thanks to the wealth of genomic, medical, and functional datasets available today. An evolutionary perspective adds a powerful dimension to these efforts by illuminating the processes that shaped our biology and explaining how and why we became who we are.

In particular, ancient genomes, including those of Neandertals and Denisovans, provide access to chapters of our evolution that were previously out of reach with present-day data alone. By integrating these ancient genomes with modern datasets, we aim to identify the genetic changes that shaped the modern human lineage and investigate their significance for human biology and health.

For a more detailed description of our research program, click here.

news

Jan 07, 2026 Recipient of the 2025 Georges Brahms Prize (CNRS Foundation)
Nov 26, 2025 ✨ The Peyrégne Lab will officially start on February 1st 2026! ✨

latest posts

selected publications

  1. Method
    Detecting ancient positive selection in humans using extended lineage sorting
    Stéphane Peyrégne, Michael James Boyle, Michael Dannemann, and 1 more author
    Genome research, 2017
  2. Article
    Nuclear DNA from two early Neandertals reveals 80,000 years of genetic continuity in Europe
    Stéphane Peyrégne, Viviane Slon, Fabrizio Mafessoni, and 8 more authors
    Science Advances, 2019
  3. Method
    AuthentiCT: a model of ancient DNA damage to estimate the proportion of present-day DNA contamination
    Stéphane Peyrégne and Benjamin M Peter
    Genome biology, 2020
  4. Review
    Present-Day DNA Contamination in Ancient DNA Datasets
    Stéphane Peyrégne and Kay Prüfer
    BioEssays, 2020
  5. Article
    The evolutionary history of human spindle genes includes back-and-forth gene flow with Neandertals
    Stéphane Peyrégne, Janet Kelso, Benjamin M Peter, and 1 more author
    eLife, 2022
  6. Review
    More than a decade of genetic research on the Denisovans
    Stéphane Peyrégne, Viviane Slon, and Janet Kelso
    Nature Reviews Genetics, 2024